Activation of the Nrf2/Keap1 signaling pathway mediates the neuroprotective effect of Perillyl alcohol against cerebral hypoxic-ischemic damage in neonatal rats

Neonatal hypoxic-ischemic encephalopathy (HIE) is a severe disease with a poor prognosis, whose clinical treatment is still limited to therapeutic hypothermia with limited efficacy.Perillyl alcohol (POH), a natural monoterpene found in various plant essential oils, has shown neuroprotective properties, though its effects on HIE are not well underst

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DAB2IP Regulates Autophagy in Prostate Cancer in Response to Combined Treatment of Radiation and a DNA-PKcs Inhibitor

Radiation therapy (RT) is an effective strategy for the treatment of localized prostate cancer (PCa) as well as local invasion.However, some locally advanced cancers develop radiation resistance and recur after therapy; therefore, the development of radiation-sensitizing compounds is essential for 70s Straight Ass Rip treatment of these tumors.DOC-

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Political ecology of asymmetric ecological knowledges: diverging views on the eucalyptus-water nexus in the Taita Hills, Kenya

Environmental resource management policies worldwide have long insisted on the need to involve local communities and their diverse ecological knowledges in management planning and decision-making.In SubSaharan post-colonial countries, however, formal resource management is still largely dominated by bureaucratic governance regimes that date back to

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